Circadian immune circuits

Circadian rhythms may shape the efficacy and strength of immune responses.

• Immune responses are regulated by specific receptors that identify antigens and microbes.
• The intensity and timing of immune responses must be controlled to minimize harm to the host.
• The circadian clock plays a key role in timing immune responses, anticipating environmental changes.
• Both immune and non-immune cells contribute to the coordination of immune responses within tissues.
• Models suggest that interactions between the central clock, structural elements, and immune cells create complex circadian circuits.

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