Gut–liver axis, nutrition, and non-alcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD) is often associated with obesity, insulin resistance, and diabetes.

• NAFLD involves a spectrum of diseases characterized by fat accumulation in the liver, inflammation, and potential progression to fibrosis and cirrhosis.
• The gut-liver axis plays a critical role in the onset and progression of NAFLD.
• The gut microbiome and intestinal barrier integrity are linked to NAFLD development.
• Dietary factors may alter gut microbiota and barrier function, contributing to metabolic endotoxemia and low-grade inflammation.
• Prebiotics and probiotics could help manage NAFLD by modulating gut microbiota and preserving intestinal barrier integrity.
• Further research is needed to clarify how dietary factors influence gut health and NAFLD pathogenesis.

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