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Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk
Gut bacteria chemical TMAO may increase platelet activity and risk of blood clots
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Abstract
Plasma TMAO levels in subjects (n > 4,000) independently predicted incident thrombosis (heart attack, stroke) risk over 3 years.
- Gut microbes may contribute to heightened platelet reactivity through the generation of trimethylamine N-oxide (TMAO).
- Direct exposure of platelets to TMAO is associated with increased activation in response to various stimuli due to enhanced calcium release.
- Animal model studies indicate that dietary choline or TMAO, along with the gut microbiota, may influence platelet responsiveness and thrombosis potential.
- Specific microbial taxa are identified as being associated with both plasma TMAO levels and thrombosis risk.
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