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Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease
Gut Microbiome Patterns Linked to Non-Invasive Detection of Advanced Scarring in Nonalcoholic Fatty Liver Disease
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Abstract
A set of 40 gut microbiota features was identified, achieving a diagnostic accuracy of 0.936 for detecting advanced fibrosis in nonalcoholic fatty liver disease (NAFLD).
- Advanced fibrosis in NAFLD is linked to increased liver mortality.
- Eighty-six patients with biopsy-proven NAFLD were analyzed, including 14 with advanced fibrosis.
- Whole-genome shotgun sequencing of stool samples was used to assess gut microbiome compositions.
- The identified features included 37 bacterial species associated with fibrosis stages.
- Preliminary evidence suggests that a fecal-microbiome-derived signature may help predict advanced fibrosis in NAFLD.
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