Gut microbiota-derived lactate is associated with disrupted cardiac circadian rhythms in alcoholic heart disease

Chronic alcohol consumption led to gut dysbiosis, characterized by an overgrowth of Akkermansia muciniphila and a depletion of Lactobacillus intestinalis and Bacteroides acidifaciens.

• Gut dysbiosis is associated with hyperlactatemia and myocardial dysfunction, indicated by reduced cardiac function and fibrosis.
• Strong dysregulation of circadian-related genes, including BHLHE41, NFIL3, and PER2, was observed in the context of Alcoholic Heart Disease.
• Interventions with dietary fiber and acetate improved microbial diversity and reduced lactate levels.
• Regulation of cardiac indicators through the lactate-circadian rhythm pathway was successfully achieved with these interventions.
• BHLHE41, NFIL3, and PER2 were identified as high-accuracy biomarkers for Alcoholic Heart Disease, with an area under the curve (AUC) greater than 0.85.

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