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Abstract
Gut microbiota dysbiosis may impair intestinal barrier integrity and promote the entry of pro-inflammatory mediators into circulation.
- Pro-inflammatory signals in the bloodstream could activate the central immune system and drive microglial polarization.
- Increased release of inflammatory factors in the brain is associated with aggravation of amyloid-β accumulation and tau phosphorylation.
- Cognitive impairment in Alzheimer's disease may be linked to neuroinflammatory cascades initiated by gut microbiota dysbiosis.
- Current intervention strategies targeting the gut microbiota-immunity-brain axis may help regulate gut microbiota balance and reduce neuroinflammation.
- Future research integrating multi-omics approaches is necessary to enhance understanding of Alzheimer's disease mechanisms.
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