Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications

Dec 10, 2024Aging and disease

How Gut Bacteria and the Immune System Interact in Health and Brain Diseases, and What This Means for Treatments

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Abstract

The human body contains approximately 100 trillion microorganisms, primarily in the gastrointestinal tract.

  • The gut microbiota is involved in communication with the brain, referred to as the microbiota-gut-brain axis.
  • This axis is a key regulator of brain development, immune system development, and nutrient metabolism.
  • The relationship between gut microbiota and neurodegenerative diseases (NDDs) is explored, focusing on gut-brain communication.
  • Alterations in gut microbiota and immune responses may be linked to neurodegeneration.
  • Potential therapeutic approaches for NDDs include probiotics, prebiotics, fecal microbiota transplantation, dietary supplements, natural drugs, and exercise.

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