Gut microbiota modulates neurotransmitter and gut-brain signaling

Neurotransmitters such as 5-hydroxytryptamine (5-HT), dopamine (DA), gamma-aminobutyric acid (GABA), and glutamate are essential for communication between the gut and brain.

• The gut microbiota may influence the metabolism of key neurotransmitters and gut-to-brain signaling.
• There is accumulating evidence linking gut microbiota to brain function and various neuropsychiatric diseases.
• Neuropsychiatric conditions such as major depression disorder, anxiety, addiction, and Parkinson's disease could be affected by the gut microbiota.
• The specific mechanisms through which gut microbiota modulate neurotransmitter function are still under investigation.
• This review aims to consolidate knowledge regarding the gut microbiota's role in neurotransmitter metabolism based on animal and clinical studies.

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