Neurotransmitter modulation by the gut microbiota

The gut microbiota influences development and diseases of both the enteric and central nervous systems.

• The gut microbiota consists of trillions of bacteria that play a crucial role in immune and metabolic health.
• Communication pathways along the 'gut-brain-axis' involve the immune system, the vagus nerve, and neuroactive compounds produced by bacteria.
• Bacteria can produce or consume various neurotransmitters, including dopamine, norepinephrine, serotonin, and GABA.
• Animal studies indicate that bacterial manipulation of neurotransmitters may affect host physiology.
• Preliminary human studies suggest that microbiota-based interventions can alter neurotransmitter levels.
• Further research is necessary to understand the physiological implications of microbiota-mediated changes in neurotransmission.

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