Gut bacteria linked to fatty liver disease not caused by alcohol

Elevated endotoxin levels in the blood may play a significant role in the pathology of nonalcoholic steatohepatitis (NASH).

• Nonalcoholic fatty liver disease (NAFLD) can progress to serious liver conditions like cirrhosis and cancer.
• The incidence of NAFLD, particularly NASH, is steadily increasing.
• Current effective treatments primarily involve dietary changes and exercise.
• Next-generation sequencing technology is revealing insights into the intestinal microbiome in NAFLD/NASH.
• Intestinal bacterial imbalance may contribute to NASH by increasing intestinal permeability and endotoxin levels.
• Targeting intestinal permeability may offer a new approach for treating NAFLD/NASH.

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