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Comprehensive Analysis of Gut Microbiota Alteration in the Patients and Animal Models with Polycystic Ovary Syndrome
Changes in Gut Bacteria in People and Animal Models with Polycystic Ovary Syndrome
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Abstract
Animal models exhibited typical PCOS symptoms, such as disordered estrous cycles and elevated testosterone levels.
- Fecal microbiota transplantation (FMT) improved PCOS symptoms in animal models.
- Microbial diversity was disordered in PCOS models, with consistent trends in the abundance of Ruminococcus and Lactobacillus in both rats and patients.
- Key genera such as Gemmiger, Flexispira, and Eubacterium were found to be overrepresented in PCOS groups.
- Restoration of microbiota diversity and certain bacterial taxa was observed after FMT.
- Gut microbiota may be involved in PCOS and could influence endocrinal and reproductive dysfunctions.
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