Inflammation and Aging in Heart Failure with Normal Pumping: Future Anti-Inflammatory Treatments
Updated
Abstract
Aging is a major risk factor for heart failure with preserved ejection fraction (HFpEF).
- Inflammaging is associated with chronic inflammation that results from aging and may contribute to heart failure.
- Mechanisms linking inflammation to HFpEF include myocardial fibrosis, increased stiffness of the heart, and fibroblast activation.
- Extracellular matrix remodeling and inflammation from adipose tissue may play significant roles in HFpEF development.
- Multimodality imaging can help identify early signs of fibrosis and inflammation in the heart.
- Emerging therapies like SGLT2 inhibitors and GLP-1 receptor agonists may modify the progression of HFpEF, while single-cytokine blockade presents limitations.
Simplified