The effect of high fat diet on daily rhythm of the core clock genes and muscle functional genes in the skeletal muscle of Chinese soft-shelled turtle (Trionyx sinensis)

A high fat diet (13.86% lipid) for six weeks disrupted the circadian rhythms of several core clock and muscle functional genes in Chinese soft-shelled turtles.

• In the control diet (7.98% lipid), 13 out of 17 core clock genes displayed circadian oscillation.
• Eight core clock genes and six muscle functional genes lost their circadian expression patterns in the high fat diet treatment.
• Five core clock genes and three muscle functional genes showed altered expression peaks when comparing high fat and control diets.
• In the control group, the expression of MyoG, MyoD, Myf6, FBXO32, and PPARa correlated with the transcription patterns of several core clock genes.
• In the high fat diet group, only FBXO32 and Myf6 correlated with the circadian expression of specific core clock genes.

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