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High-fat diet changes the temporal profile of GLP-1 receptor-mediated hypophagia in rats
High-fat diet changes how long GLP-1 receptor reduces eating in rats
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Abstract
Rats on a high-fat diet exhibited a delayed acute response to GLP-1 receptor agonists, with effects lasting longer compared to those on a low-fat diet.
- High-fat diets (40% or 81% kcal from fat) influence gut-brain communication related to energy balance.
- Rats on high-fat diets showed a delayed initial reduction in food intake after administration of GLP-1 receptor agonists Exendin-4 or liraglutide.
- Once the reduction in food intake began, it lasted longer in high-fat diet-fed rats than in low-fat diet-fed rats.
- Central administration of Exendin-4 suppressed food intake similarly in both high-fat and low-fat diet-fed rats.
- Chronic high-fat diet consumption increased intestinal GLP-1 receptor expression while decreasing hindbrain GLP-1 receptor expression.
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