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Effect of high-fat diet on mechanosensitive transient receptor potential channel activation in vagal afferent neurons
High-fat diet’s impact on pressure-sensitive channels in nerve cells that send signals from the gut
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Abstract
High-fat diet-fed mice showed reduced calcium response and jejunal afferent activity induced by TRPV4 and TRPA1 activation.
- Chronic high-fat diet may impair the activation of specific mechanosensitive ion channels in the vagus nerve.
- Reduced intracellular calcium influx in nodose neurons was observed in response to mechanical stimulation in high-fat diet-fed mice.
- Jejunal afferent nerve firing in response to mechanical stimuli and TRP channel agonists was decreased in high-fat diet conditions.
- The disruption of TRPV4 and TRPA1 activation may be linked to decreased sensitivity of vagal afferents to mechanical signals.
- These findings are associated with reduced gut-brain signaling related to satiety in obesity.
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