Factors influencing individual variability in high fat diet-induced weight gain in out-bred MF1 mice

Weight changes in mice on a high-fat diet ranged from -1% to 26%.

• Fat-free mass before high-fat diet exposure predicted 12% of the variability in weight gain on the diet.
• Food intake during the first week of high-fat diet feeding predicted 20% of the variability in body mass and fat mass gain four weeks later.
• Weight gain on the high-fat diet was significantly negatively correlated with weight loss during caloric restriction.
• Mice that gained weight poorly on the high-fat diet also struggled to lose weight during caloric restriction.
• Changes in fat mass and fat-free mass in response to the high-fat diet or caloric restriction were not correlated.

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