Effects of a 3-week High-Fat-Low-Carbohydrate Diet on Lipid and Glucose Profiles in 8 Experienced, Middle-age Male Runners

Jun 4, 2019International journal of exercise science

Effects of a 3-Week High-Fat, Low-Carb Diet on Blood Fat and Sugar Levels in Experienced Middle-Age Male Runners

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Abstract

A 3-week low-carbohydrate-high-fat diet resulted in a significant increase of ~20 mg/dL in LDL cholesterol levels.

Glucose levels improved during the low-carbohydrate-high-fat diet but did not reach statistical significance (p = 0.07).
Triacylglycerol levels decreased by more than 20 mg/dL for both dietary conditions when comparing pre-exercise and post-exercise measurements (p < 0.05).
HDL cholesterol levels were higher in the low-carbohydrate-high-fat diet compared to the habitual mixed macronutrient diet during both fasting and post-exercise conditions.
Total cholesterol was approximately 30 mg/dL greater for the low-carbohydrate-high-fat diet before and after exercise (p < 0.05).
No significant negative cardiovascular disease risk was observed in male runners aged 30-50 years following the low-carbohydrate-high-fat diet.

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This study examined glucose and lipid marker responses following a 3-week, ad libitum low-carbohydrate-high-fat diet (LCHF; ~70% kcals from fat, <50 g/day of net carbohydrates) versus the habitual mixed macronutrient diet (HMD) of eight middle-age, trained male runners (40 ± 10 years; V̇Opeak = 49 ± 4 mL·kg·min). Blood was drawn at 0600 from an antecubital vein after an overnight fast under conditions of no exercise/heat stress (NEXH; 48 h of restriction from intense exercise) or 24-h after exercise/heat stress (EXH; 60 min run in hot conditions plus 5-km time trial) for both dietary conditions. Glucose improvement during LCHF approached but did not reach statistical significance (p = 0.07). Pre-exercise triacylglycerol did not differ between treatments but decreased > 20 mg/dL (p < 0.05) for both treatments from NEXH to EXH (HMD = 42 ± 16; LCHF = 35 ± 21 mg/dL). Main effects for diet were exhibited for HDL-C during NEXH and EXH (HMD = 48 ± 10 and 50 ± 11; LCHF = 57 ± 13 and 60 ± 13 mg/dL), and LDL-C also increased (p = 0.02) by ~20 mg/dL for LCHF at both collection points resulting in ~30 mg/dL greater total cholesterol for LCHF before and 24-h after exercise (p < 0.05). A 3-week, ad libitum LCHF did not elicit significant negative cardiovascular disease risk in male runners 30-50 years of age with healthy pre-intervention lipid and glucose marker status. 2 -1 -1

Effects of a 3-week High-Fat-Low-Carbohydrate Diet on Lipid and Glucose Profiles in 8 Experienced, Middle-age Male Runners

Abstract

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