A 3-Week, Low-Carbohydrate, High-Fat Diet Improves Multiple Serum Inflammatory Markers in Endurance-Trained Males

Seven inflammatory markers showed significant improvement with a low-carbohydrate, high-fat diet in endurance-trained males.

• The study involved eight middle-aged male runners who switched from a habitual mixed diet to a low-carbohydrate, high-fat diet for three weeks.
• Fasting serum samples were collected immediately after exercise and again 24 hours later to assess inflammation markers.
• Statistically significant reductions in seven inflammation markers were observed with the low-carbohydrate, high-fat diet compared to the habitual mixed diet.
• One marker, sCD30, displayed a notable decrease both before and after exercise with the low-carbohydrate, high-fat diet.
• The findings suggest that a low-carbohydrate, high-fat diet may provide some protective effects against chronic inflammation in physically active men aged 30 to 50.

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