The relationship between homeostasis model assessment and cardiovascular risk factors in Iranian subjects with normal fasting glucose and normal glucose tolerance

May 23, 2006Clinica chimica acta; international journal of clinical chemistry

How insulin resistance relates to heart risk factors in Iranians with normal blood sugar levels

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Abstract

Among 605 subjects, women exhibited higher HOMA-IR values than men.

Insulin resistance was more prevalent in women than men across both age groups.
Women showed higher rates of general and abdominal obesity, low HDL cholesterol, and physical inactivity.
Men aged 25-50 had a greater prevalence of hypertension and high triglycerides.
HOMA-IR was significantly correlated with triglycerides and inversely associated with HDL cholesterol for both sexes.
In women with HOMA-IR values greater than 2.39, there was a notably higher prevalence of hypertension, obesity, and low HDL cholesterol.
Multiple regression analysis indicated that factors predicting HOMA-IR differed between sexes.

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BACKGROUND: Insulin resistance is a complex problem which may not always correlate with all its cardiovascular risk factors in various populations. We investigated the relationship between homeostasis model assessment of insulin resistance (HOMA-IR) with cardiovascular risk factors in Iranian subjects with normal fasting glucose (NFG) and normal glucose tolerance (NGT).

METHODS: Of the 605 subjects aged 25-79 y enrolled in this study, after the oral glucose tolerance test, 366 subjects aged 25-50 y and 135 aged >50 y were classified as NFG and NGT. Insulin resistance was estimated by the HOMA-IR.

RESULTS: Women had higher values of body mass index (BMI), insulin and HOMA-IR than men in both age groups. The prevalence of insulin resistance, general and abdominal obesity, low HDL-C and physical inactivity was higher in women than men in the 2 age groups. Men had a higher prevalence of hypertension and hypertriglyceridemia in the group with age 25-50 y. The Pearson correlation controlled for age, BMI, waist circumference and physical activity showed that HOMA-IR had significant correlation with triglyceride and inversely associated with HDL-C in both sexes. In addition, the results of HOMA-IR quartiles demonstrated that the prevalence of hypertension, obesity, and low HDL-C was particular high in women with HOMA-IR >2.39. Multiple regression indicated that log HOMA-IR was independently predicted by BMI, triglyceride and HDL-C in men and BMI, HDL-C and waist-to-hip (WHR) ratio in women.

CONCLUSIONS: HOMA-IR is associated with the features of metabolic syndrome with a sex difference in the degree and predictors of HOMA-IR and the frequency of cardiovascular risk factors.

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The relationship between homeostasis model assessment and cardiovascular risk factors in Iranian subjects with normal fasting glucose and normal glucose tolerance

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