Hypertriglyceridemia is associated with increased insulin resistance in subjects with normal glucose tolerance: Evaluation in a large cohort of subjects assessed with the 1999 World Health Organization criteria for the classification of diabetes

A very significant correlation was found between insulin resistance and plasma triglycerides (r = 0.27, P < 1.02E(-10)).

• Insulin resistance was calculated using a specific formula based on fasting serum insulin and glucose levels.
• Higher plasma triglyceride levels were linked to increased insulin resistance, particularly in subjects within the upper two tertiles of triglycerides.
• Subjects with elevated triglycerides tended to be older and had higher body mass index (BMI) values compared to those with lower triglycerides.
• A positive trend was noted for several cardiovascular risk factors, including blood pressure, fasting blood glucose, fasting serum insulin, and total cholesterol, with higher triglyceride levels.
• Conversely, lower levels of high-density lipoprotein cholesterol (HDL-C) were associated with higher triglycerides.

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