Using fasting C-peptide instead of insulin to assess insulin resistance and insulin-producing cell function

The modified Homa formula demonstrated a correlation of r = 0.689 for insulin resistance and r = 0.788 for islet beta cell function.

• A new formula for assessing insulin resistance using fasting C-peptide was developed and correlated with traditional methods.
• The modified Homa-IR formula includes fasting blood glucose and fasting C-peptide levels as variables.
• Fasting C-peptide may effectively replace insulin in evaluating insulin resistance and islet beta cell function.
• The modified assessments showed similar results in both normal and diabetic subjects.

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