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Abstract
Essence
Human genetic analyses suggest thromboembolism may contribute to long COVID in people of European ancestry.
Evidence
This host-genetics analysis in the Long COVID Host Genetics Initiative found genetically predicted venous thromboembolism risk was associated with 1.21-fold higher odds of long COVID and pointed to PAR-1 in downstream analyses.
Caveat
The evidence is genetic association in European-ancestry datasets rather than direct mechanistic or interventional proof, so generalizability and causality remain limited.
Simplified