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The Human Myometrium as a Target for Melatonin
Melatonin’s effects on the muscle layer of the human uterus
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Abstract
Births occur statistically more often during the nocturnal phase of the 24-hour cycle.
- Melatonin receptors MT1 and MT2 were found in myometrial biopsies from both pregnant and nonpregnant women.
- High affinity binding of iodomelatonin to myometrial tissues was demonstrated in both groups.
- Myocytes exhibited different responses to melatonin in cAMP signaling based on the reproductive state.
- These findings suggest that melatonin may play a role in regulating myometrial function.
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