Melatonin’s effects on the muscle layer of the human uterus

Births occur statistically more often during the nocturnal phase of the 24-hour cycle.

• Melatonin receptors MT1 and MT2 were found in myometrial biopsies from both pregnant and nonpregnant women.
• High affinity binding of iodomelatonin to myometrial tissues was demonstrated in both groups.
• Myocytes exhibited different responses to melatonin in cAMP signaling based on the reproductive state.
• These findings suggest that melatonin may play a role in regulating myometrial function.

Simplified