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Abstract
A comprehensive analysis of 516 samples from 13 human tissues reveals key insights into the proteomics of aging.
- Significant transcriptome-proteome decoupling is observed across various human tissues as they age.
- Proteostasis decline is characterized by the accumulation of amyloid proteins.
- Tissue-specific proteomic age clocks were developed based on aging-associated protein changes.
- An aging inflection point is noted around age 50, with blood vessels identified as particularly susceptible to early aging.
- A plasma proteomic signature of aging aligns with its tissue origins and includes candidate senoproteins like GAS6.
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