Hyperprolactinemia and Brain Health: Exploring the Gut-Brain Axis and Therapeutic Strategies

Nov 19, 2025Molecular neurobiology

High Prolactin Levels, Gut-Brain Communication, and Possible Treatments for Brain Health

AI simplified

Gut-Brain Axis on OpenScience ↗PubMed ↗DOI ↗

Abstract

Hyperprolactinemia is associated with elevated prolactin levels in the serum and may affect brain health.

Prolactin is known for its role in milk secretion but also influences brain health and central nervous system functions.
The gut-brain axis is an important focus in neuroscience, revealing interactions between the gastrointestinal system and the brain.
Hyperprolactinemia may contribute to various neurological disorders, necessitating further investigation into its mechanisms.
Future research could explore probiotic therapies or dietary and lifestyle changes to optimize gut microbiota for brain health.
There is potential for targeting prolactin in the treatment of neurodegenerative and mental health conditions.

AI simplified

Prolactin is a pituitary anterior lobe hormone that plays a crucial role in milk secretion from the mammary glands. Hyperprolactinemia is a common endocrine disorder characterized by abnormally elevated levels of prolactin in the serum. Recent research findings indicate that prolactin also exerts important physiological effects beyond lactation, including effects on brain health and the central nervous system. The gut-brain axis has become an important area of neuroscience research, providing insights into the complex interactions between the gastrointestinal system and the central nervous system. Future research may involve developing new probiotic therapies or optimizing the gut microbiota through dietary and lifestyle interventions. In addition, understanding the mechanisms by which hyperprolactinemia contributes to various neurological disorders and targeting prolactin for treatment are crucial areas of research. Therefore, this study aimed to investigate the correlation between hyperprolactinemia and brain health from the perspective of the gut-brain axis, with the goal of discovering new approaches for preventing and treating neurodegenerative and mental health conditions. This synthesis highlights potential strategies for future therapeutic interventions.

Full Text

Full text is available at the source.

View full text (PDF) ↗View full text (HTML) ↗

Hyperprolactinemia and Brain Health: Exploring the Gut-Brain Axis and Therapeutic Strategies

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the gut-brain axis brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the gut-brain axis brief