Sheng li ke xue jin zhan [Progress in physiology]

The brain's internal clock and the pineal gland in controlling daily rhythms in mammals

Circadian Biology Weekly Brief ↗PubMed ↗

Updated

Abstract

Melatonin may regulate circadian activity in the suprachiasmatic nucleus (SCN) through high affinity receptors.

  • The suprachiasmatic nucleus (SCN) is a central circadian pacemaker in mammals.
  • SCN has its own intrinsic rhythm and is influenced by light and certain chemicals.
  • Melatonin, produced by the pineal gland, is regulated by the SCN.
  • Melatonin activates specific signaling pathways that affect SCN activity.
  • The influence of melatonin on SCN regulation is time-sensitive.

Simplified

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