Repercussions of hypo and hyperthyroidism on the heart circadian clock

Chronic hypo and hyperthyroidism significantly alters mRNA levels of core clock genes in the heart.

• Time-of-day-dependent oscillations in cardiac gene expression are linked to the intrinsic circadian clock in heart cells.
• Alterations in mRNA levels of core clock components were observed in both hypo and hyperthyroid conditions, except for Per2 during hyperthyroidism.
• Key metabolism-related genes that are influenced by the circadian clock also showed changes in expression levels, particularly under hypothyroid conditions.
• These findings indicate that thyroid status may disrupt normal 24-hour rhythms in heart gene expression.
• The potential relationship between these disruptions and cardiac dysfunction in hypo and hyperthyroidism is still unclear.

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