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Immune‐mediated diseases and risk of Crohn’s disease or ulcerative colitis: a prospective cohort study
Immune-related diseases and their link to Crohn's disease or ulcerative colitis risk
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Abstract
Over 2 million person-years of follow-up revealed that individuals with one or more immune-mediated diseases (IMDs) have a 2.57 to 2.74 times higher risk of developing Crohn's disease (CD).
- A total of 132 cases of CD and 186 cases of ulcerative colitis (UC) were documented during the study period.
- The increased risk for CD was observed in individuals with a history of one or more IMDs, with hazard ratios of 2.57 for one IMD and 2.74 for two or more IMDs.
- Adjustment for environmental risk factors only modestly reduced the association, with hazard ratios of 2.35 and 2.46 for those with one and two or more IMDs, respectively.
- No increased risk for UC was found in individuals with one or more IMDs, as the hazard ratios were 1.22 for one IMD and 1.33 for two or more IMDs.
- Specific IMDs such as asthma, atopic dermatitis, psoriasis, and rosacea were individually linked to a higher risk of CD, with hazard ratios ranging from 2.15 to 3.39.
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