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The immunometabolic reprogramming of microglia in Alzheimerʼs disease
Changes in immune and energy use of brain immune cells in Alzheimer's disease
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Abstract
Microglia in Alzheimer's disease may exhibit altered energy metabolism linked to immune functions.
- Microglia can be activated into different types that have varying effects on inflammation and energy use.
- Changes in microglial metabolism may influence their ability to respond to environmental signals.
- The review highlights the importance of mitochondria in the energy needs of microglia during immune responses.
- Understanding metabolic reprogramming in microglia could inform new treatment strategies for Alzheimer's disease.
- Drugs that affect microglial metabolism may help reduce neuroinflammation associated with Alzheimer's.
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