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Immunosenescence in digestive system cancers: Mechanisms, research advances, and therapeutic strategies
Aging of the Immune System in Digestive Cancers: How It Happens, Recent Findings, and Treatment Approaches
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Abstract
Immunosenescence is associated with the increase of age-related diseases, particularly cancer.
- A decrease in immune surveillance due to immunosenescence is linked to cancer progression.
- Senescent cancer cells may enhance the recruitment and function of immune-suppressive cell types.
- Age-related damage to the intestinal mucosal barrier could weaken local immune responses.
- The aging of gut-associated lymphoid tissue and dysbiosis may contribute to vulnerabilities in the immune microenvironment.
- Research progress on immunosenescence and immune microenvironments in digestive system cancers is reviewed.
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