Full text is available at the source.
Abstract
Autoimmune diseases (AIDs) are associated with various changes in the immune system due to aging and immunosenescence.
- Immunosenescence involves multiple alterations in the immune system, including changes in self-antigens and lymphocyte function.
- Aging may increase susceptibility to autoimmune diseases by narrowing the diversity of B and T cell receptors.
- Senescent immune cells contribute to chronic inflammation and tissue damage in autoimmune diseases.
- Mitochondrial dysfunction and metabolic imbalances may lead to an accumulation of senescent cells, driving immunosenescence.
- Therapeutic strategies targeting immunosenescence in autoimmune diseases are still in early development.
Simplified