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Hallmarks of aging and immunosenescence: Connecting the dots
Key Signs of Aging and Immune System Decline: Understanding the Links
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Abstract
Aging is associated with the loss of homeostasis and can lead to negative health consequences.
- Cellular senescence occurs when cells can no longer renew themselves, halting the cell cycle.
- Immunosenescence, or the aging of the immune system, can induce senescence in other tissues.
- Aging alters immune functionality, impacting the ability to fight infections and increasing susceptibility to chronic diseases like cancer and cardiovascular disease.
- The senescence-associated secretory phenotype may induce senescence in otherwise healthy cells.
- Inflammaging is linked with various comorbidities, necessitating understanding for potential therapeutic targets.
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