Should we Try to Alleviate Immunosenescence and Inflammaging - Why, How and to What Extent?

Aging is associated with two major features of the immune system: immunosenescence and inflammaging.

• The effectiveness of immune responses declines with advancing age, impacting the body's ability to combat external and internal pathogens.
• Immunosenescence refers to the gradual deterioration of the immune system's function as individuals age.
• Inflammaging is characterized by chronic, low-grade inflammation that occurs with aging, which may have both detrimental and potentially beneficial effects.
• The immune system has evolved regulatory mechanisms to manage its responses, which can become less effective over time due to age-related changes.
• Understanding the balance between the negative and positive aspects of immunosenescence and inflammaging could inform therapeutic strategies for immune system management in older adults.

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