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Abstract
A subclinical syndrome of homeostatic frailty is associated with immune debilitation and chronic low-grade inflammation in the elderly.
- Aging progressively undermines the immune system's ability to maintain tissue homeostasis.
- The balance between myeloid and lymphoid responses is crucial for proper immune function.
- Homeostatic frailty may predispose elderly individuals to chronic and degenerative diseases.
- Alterations in the innate immune compartment include changes in myeloid progenitor differentiation.
- These age-dependent changes could affect responses to both internal and external threats.
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