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Abstract
Immunosenescence, the age-related decline of immune function, drives a state of chronic inflammation known as inflammaging.
- Immunosenescence is characterized by erosion of lymphoid organs and a shift in blood cell production towards myeloid cells.
- Accumulation of immune-evasive senescent cells contributes to the decline in immune function.
- Metabolic and epigenetic changes may lock cells into dysfunctional states, perpetuating a cycle of pathology.
- Emerging therapeutic strategies focus on targeting specific aspects of the immunosenescence network.
- Interventions include senotherapeutics for clearing senescent cells, rejuvenation of blood cell production, and metabolic corrections.
- A precision medicine framework is suggested to improve healthspan by separating protective immunity from harmful processes.
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