Impaired Glucocorticoid Production and Response to Stress in Arntl-Deficient Male Mice

Genetic removal of the Arntl gene in mice is associated with hypocortisolism and impaired stress responses.

• Arntl-deficient mice exhibit loss of normal 24-hour rhythms in physiology and behavior.
• These mice have reduced adrenal responsiveness to ACTH, indicating impaired hormone release.
• Transcription of genes related to cholesterol transport in the adrenal glands is down-regulated in Arntl-deficient mice.
• Under stress, these mice show diminished glucocorticoid release and altered behavioral responses.
• The absence of Arntl may enhance resistance to acute and repeated stress through its effect on adrenal function.

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