Reduced stress hormone production and response in male mice lacking the Arntl gene

Genetic removal of the Arntl gene in mice is associated with hypocortisolism and impaired stress responses.

• Arntl-deficient mice exhibit loss of normal 24-hour rhythms in physiology and behavior.
• These mice have reduced adrenal responsiveness to ACTH, indicating impaired hormone release.
• Transcription of genes related to cholesterol transport in the adrenal glands is down-regulated in Arntl-deficient mice.
• Under stress, these mice show diminished glucocorticoid release and altered behavioral responses.
• The absence of Arntl may enhance resistance to acute and repeated stress through its effect on adrenal function.

Simplified