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Abstract
Effective delivery of therapeutic agents requires both sufficient cellular uptake and the ability to escape from endosomes.
- Endosomal entrapment poses a significant barrier to the efficacy of therapeutic biomolecules.
- Most cargo delivered to cells is often sequestered in endosomes, risking degradation or exocytosis.
- Natural strategies from pathogens, such as membrane fusion and pore formation, may enhance therapeutic delivery.
- Emerging technologies aim to leverage these natural mechanisms to improve the bioavailability of therapeutic agents.
- Optimizing cargo delivery necessitates integrating insights from cellular biology with translational design.
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