Full text is available at the source.
Abstract
Lipid nanoparticles encapsulating mRNA achieved measurable transfection efficiency in HepG2 cells and demonstrated bioluminescence in C57BL/6 mice.
- Lipid nanoparticles serve as delivery platforms that protect mRNA from degradation and facilitate its delivery into cells.
- The formulation of mRNA-lipid nanoparticles was achieved through microfluidic mixing of lipid components and mRNA.
- In vitro tests showed that these mRNA-lipid nanoparticles effectively transfected HepG2 cells.
- In vivo testing demonstrated detectable whole-body bioluminescence in mice following intravenous injection of the mRNA-lipid nanoparticles.
- Results indicate the potential of mRNA-lipid nanoparticles as a delivery system for therapeutic applications.
Simplified