Metabolism: clinical and experimental

New incretin and multi-target treatments expanding options for heart, kidney, liver, and metabolic diseases

Updated

Abstract

Innovative incretin- and multi-agonist-based therapies may deliver an increasing double-digit percent weight loss.

  • Molecular pathways associated with GLP-1, GIP, amylin, glucagon, and peptide YY are linked to improved outcomes in obesity and related disorders.
  • Research is ongoing into single, dual, and triple drug combinations in various phases of clinical trials.
  • The development of unimolecular multi-receptor activating drugs is facilitated by similarities in peptide sequences.
  • Clinical trials and real-world evidence support the potential effectiveness of incretin and multi-agonist therapies.
  • Early initiation of incretin-based therapy may improve body weight and cardiovascular risk management across various disorders.

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Full Text

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Funding

Competing interests

Declaration of competing interest EM has given talks or attended conferences sponsored by Novo Nordisk, Boehringer Ingelheim, AstraZeneca, Medtronic, Merck Sharp & Dohme, Novartis, Sanofi, and Servier. NK has given talks, attended conferences and participated in trials sponsored by Amgen, Astra Zeneca, Boehringer Ingelheim, Elpen, Libytec, Menarini, Novartis, Novo Nordisk, Sanofi, Recordatti and Viatris. ŠV has given talks or attended conferences sponsored by Eli Lilly, Novo Nordisk, Boehringer Ingelheim, Sanofi, Medtronic, and Abbott. MR has given lectures, received honoraria and research support, and participated in conferences, advisory boards, and clinical trials sponsored by several pharmaceutical companies including Amgen, Astra Zeneca, Boehringer Ingelheim, Kowa, Eli Lilly, Meda, Mylan, Merck Sharp & Dohme, Novo Nordisk, Novartis, Roche Diagnostics, Sanofi, and Servier. CSM reports grants through his institution from Merck and Boehringer Ingellheim, has received grants through his Institution and personal consulting fees from Coherus Inc. and AltrixBio, he reports personal fees from Novo Nordisk, reports personal fees and support with research reagents from Ansh Inc., collaborative research support from LabCorp Inc., reports personal fees from Genfit, Lumos, Amgen, Corcept, Intercept, and Regeneron, reports support (educational activity meals through his institution or national conferences) from Amarin, Novo Nordisk, Astra Zeneca, Boehringer Ingelheim and travel support and fees from TMIOA, Elsevier, the California Walnut Commission, College Internationale Researche Servier, and the Cardio Metabolic Health Conference. None is directly related to the work presented herein. As EIC he was not involved in handling this manuscript which was handled by an Associate Editor overseeing the special issue. Other authors declare no conflict of interest.
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