Injectable Inflammation‐Responsive Hydrogels for Microenvironmental Regulation of Intervertebral Disc Degeneration

An injectable drug-loaded hydrogel shows promising therapeutic effects on intervertebral disc degeneration.

• Chronic local inflammation and excessive cell death in nucleus pulposus tissue are key factors in intervertebral disc degeneration.
• The hydrogel is designed to respond to pH changes and reactive oxygen species, enhancing its drug delivery capabilities.
• It demonstrates superior drug loading capacity for certain drugs and effective radical scavenging, indicating potential for reducing oxidative stress.
• The hydrogel exhibits significant antibacterial properties and favorable biocompatibility with NP cells.
• In vivo results suggest improvements in water retention, restoration of disc height, and promotion of NP cell regeneration.

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