Effects of injectable weight-loss drugs on reproductive health in women without polycystic ovary syndrome

GLP-1 receptor agonists are associated with lower ovarian weights and altered hormone levels in animal models.

• Studies in animals show varied effects of different GLP-1 receptor agonists on reproductive health.
• In ovaries, these medications led to increased follicular atresia and reduced serum steroid levels.
• Changes in the hypothalamus included decreased expression of certain genes, resulting in lower luteinizing hormone levels and delayed puberty.
• GLP-1 receptor agonists negatively affected the uterine epithelium but reduced uterine fibrosis in a specific mouse model.
• There is a lack of human studies investigating the impact of GLP-1 receptor agonists on fertility in women without PCOS.

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