The number of signs compatible with decreased from 3.3±0.1 to 1.4±0.1 after treatment.
improved by +93% and +425% at two different sites.
The Standard Patient Evaluation of Eye Dryness score decreased by -55%.
Meibomian gland score improved by -36%.
Corneal fluorescein staining reduced by -58%.
Tear film osmolarity improved by -7% in eyes with elevated baseline levels.
Lipid layer thickness showed no significant change.
Simplified
PURPOSE: The aim of this study was to estimate the efficacy of intense pulsed light (IPL), followed by meibomian gland expression (MGX), for reducing the number and severity of signs and symptoms of (DED) secondary to (MGD).
PATIENTS AND METHODS: In a prospective study conducted in two sites, 40 subjects (80 eyes) with moderate to severe MGD were enrolled. Major inclusion criteria consisted of at least two of the following measures being compatible with DED in both eyes: (TBUT), meibomian gland score (MGS), corneal fluorescein staining (CFS), Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire, and tear film osmolarity (TFO). Enrolled patients underwent four treatment sessions, 3 weeks apart. Each treatment included the administration of 10-15 pulses of IPL on the cheeks and nose, followed by MGX of the upper and lower eyelids. TBUT, MGS, CFS, SPEED, TFO, and lipid layer thickness (LLT) were measured at baseline (BL) and at 9, 12, and 15 weeks after BL.
RESULTS: Due to different staining methods used for TBUT measurements, TBUT and CFS were analyzed separately for each site. From BL to the final follow-up, the number of signs compatible with DED decreased from 3.3±0.1 to 1.4±0.1. TBUT improved by +93% (n=38;<0.0001) and +425% (n=42;<0.0001) for sites 1 and 2, respectively. SPEED, MGS, and CFS improved by -55% (n=80;<0.0001), -36% (n=80;<0.0001), and -58% (n=38;<0.0001), respectively. In 20 eyes with abnormally elevated TFO at BL, TFO improved by -7% (n=20;<0.005). LLT did not change (n=38;=0.88). P P P P P P P
CONCLUSION: In subjects with moderate to severe MGD, IPL combined with MGX reduced the number and severity of symptoms and signs of DED. Except for LLT, all examined outcome measures significantly improved after 15 weeks. These results support the efficacy of IPL + MGX in relieving both signs and symptoms of DED secondary to MGD.
Key numbers
+425%
Increase in
Improvement from baseline to final follow-up at site 2.
-55%
Decrease in SPEED Score
Average change from baseline to final follow-up.
-36%
Decrease in Meibomian Gland Score
Average change from baseline to final follow-up.
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