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Intestinal production of melatonin and its putative role as a circadian organizer
Melatonin made in the gut and its possible role in regulating the body’s daily rhythms
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Abstract
AANAT expression in the intestine of rats shows a clear circadian pattern, particularly in the proximal and distal regions.
- Intestinal melatonin may play a role in local metabolic organization.
- AANAT expression varies along the intestine, with rhythmic patterns observed in both the duodenum and colon.
- Fasting abolishes the circadian variation in AANAT expression in the duodenum, suggesting it is not self-sustained.
- The colon exhibits the highest AANAT expression with rhythmic activity; however, this rhythm is not synchronized to feeding.
- Intestinal melatonin likely originates from different populations of secreting cells, none of which fulfill the criteria for a pacemaker in the Food-Entrainable Oscillator.
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