After 3 months of treatment, dietary improved sex hormone disorders and reduced BMI and WHR levels in obese women with .
Dietary inulin reduced plasma levels of inflammatory markers TNF-α, IL-1β, IL-6, and MCP-1.
Inulin treatment increased the abundance of beneficial gut bacteria such as Actinobacteria, Fusobacteria, and Bifidobacterium.
The ratio of Firmicutes to Bacteroidetes (F/B) decreased following inulin intervention.
A strong correlation was observed among plasma inflammatory factors, sex steroid hormones, and the intestinal flora in patients.
Simplified
CONTEXT: (PCOS), a common endocrine disorder in women of reproductive age, is closely associated with chronic low-grade inflammation and metabolic disturbances. In PCOS mice, dietary has been demonstrated to regulate intestinal flora and inflammation. However, the efficacy of dietary inulin in clinical PCOS remains unclear.
OBJECTIVE: The intestinal flora and related metabolic indexes of obese patients with polycystic ovary syndrome (PCOS) after 3 months of inulin treatment were analyzed.
SETTING AND DESIGN: To analyze the intestinal flora and related metabolic indexes in healthy controls and obese patients with polycystic ovary syndrome after 3 months of inulin treatment.
RESULTS: The results showed that dietary inulin improved sex hormone disorders, reduced BMI and WHR levels in obese women with PCOS. In addition, the inulin intervention reduced plasma TNF-α, IL-1β, IL-6, and MCP-1levels. Inulin intervention increased the abundance of Actinobacteria, Fusobacteria, Lachnospira, and Bifidobacterium, as well as decreased the ratio of F/B and the abundance of proteobacteria, Sutterella, and Enterobacter. Correlation analyses showed a strong relationship among plasma inflammatory factors, sex steroid hormones, and the intestinal flora of patients.
CONCLUSIONS: Dietary inulin may improve obese PCOS women disease through the gut flora-inflammation-steroid hormone pathway.
THE CLINICAL TRIAL REGISTRATION NUMBER: ChiCTR-IOR-17012281.
Key numbers
0.046
Decrease in BMI
Statistical significance of BMI reduction after intervention.
Significant increase
Increased Actinobacteria abundance
Change in gut microbiota composition after treatment.
Significant decrease
Decrease in inflammatory markers
Reduction in plasma inflammatory markers after treatment.
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