Irritable bowel syndrome: a gut microbiota-related disorder?

Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders, affecting a significant portion of the population.

• Alterations in gut microbiota may play a role in the pathophysiology of IBS.
• Factors such as host genetics, stress, diet, antibiotics, and early life experiences could influence gut microbiota in individuals predisposed to IBS.
• Disrupted communication between the gut and brain, known as the gut-brain axis, may be affected by gut microbiota.
• Visceral hypersensitivity and altered gastrointestinal motility are mechanisms potentially influenced by changes in gut microbiota.
• Epithelial barrier dysfunction and immune activation are also associated with gut microbiota alterations in the context of IBS.

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