Ischemic colitis linked to oral semaglutide with return after restarting the drug

Ischemic colitis may be a rare adverse effect associated with oral semaglutide treatment.

• A 46-year-old woman experienced three episodes of abdominal pain and rectal bleeding while taking semaglutide.
• The diagnosis of ischemic colitis was confirmed through imaging and tissue analysis.
• Complete resolution of symptoms occurred after discontinuation of semaglutide.
• Recurrence of symptoms followed the reintroduction of the drug, suggesting a possible link.
• Only a few cases of ischemic colitis related to GLP-1 receptor agonists have been documented.

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