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KaiB functions as an attenuator of KaiC phosphorylation in the cyanobacterial circadian clock system
KaiB reduces KaiC phosphorylation in the cyanobacteria’s daily biological clock
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Abstract
A circadian rhythm in the localization of KaiB was observed in the cyanobacterium Synechococcus elongatus PCC 7942.
- KaiB interacts with a KaiA-KaiC complex during the late subjective night.
- The binding of KaiB to KaiC leads to a significant decrease in KaiC phosphorylation.
- Dissociation of the clock protein complex occurs following the binding of KaiB and KaiC.
- KaiB reduces the phosphorylation enhancement effect of KaiA in both laboratory and living systems.
- These findings suggest a new role for KaiB in linking localization, interactions, and modifications of Kai proteins within the cyanobacterial circadian clock.
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