Physical interactions among circadian clock proteins KaiA, KaiB and KaiC in cyanobacteria

Mar 4, 1999The EMBO journal

Physical interactions between daily rhythm proteins KaiA, KaiB, and KaiC in cyanobacteria

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Abstract

The kai gene cluster is essential for generating circadian rhythms in the unicellular cyanobacterium Synechococcus sp. strain PCC 7942.

  • KaiA, KaiB, and KaiC proteins directly associate in yeast cells and cyanobacterial cells.
  • KaiC enhances the interaction between KaiA and KaiB in both in vitro and yeast systems.
  • A long period mutation, kaiA1, significantly increases the interaction between KaiA and KaiB in vitro.
  • Direct interactions among the Kai proteins may be critical for circadian rhythm generation in cyanobacteria.

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