Ketamine’s effectiveness in hard-to-treat depression may vary by depression type and childhood trauma history

Preliminary results suggest that biomedical ketamine may be superior in treating melancholic depression compared to non-melancholic depression.

• The study explores different models of ketamine treatment for treatment-resistant depression (TRD).
• A comparison is made between biomedical approaches and psychedelic-assisted therapy for TRD.
• Differential efficacy based on depressive subtype and childhood trauma is investigated.
• The Sydney Melancholia Prototypic Index is used to subtype patients' depression.
• Current studies on ketamine as a psychedelic combined with psychotherapy are limited.

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