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Abstract
Lactobacillus plantarum ZDY04 reduced serum TMAO and cecal TMA levels in mice fed 1.3% choline.
- TMAO, a compound linked to atherosclerosis, is produced from TMA by liver enzymes.
- Dietary choline is converted to TMA by intestinal bacteria, which can lead to increased TMAO levels.
- Five probiotic strains were tested, but only L. plantarum ZDY04 effectively lowered serum TMAO and cecal TMA.
- L. plantarum ZDY04 altered the balance of certain intestinal bacteria families without affecting liver enzyme expression.
- Mice treated with L. plantarum ZDY04 showed reduced development of atherosclerosis caused by TMAO.
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